Publication details
Maligní hypertermie
| Title in English | Malignant Hyperthermia |
|---|---|
| Authors | |
| Year of publication | 2004 |
| Type | Article in Periodical |
| Magazine / Source | Anesteziologie & Intenzivní medicína |
| MU Faculty or unit | |
| Citation | |
| Web | http://www.clsjep.cz |
| Field | Surgery incl. transplantology |
| Keywords | maligní hypertermie - presymptomatická diagnostika - Národní centrum pro maligní hypertermie ČR |
| Description | Malignant hyperthermia is a serious complication of general anaesthesia. It is a genetically determined disposition with an autosomal dominant transfer. The development of MH is conditioned by the exposure to triggering agents - inhalation anaesthetics and suxamethonium. The nature of MH is a disorder of calcium metabolism in sarcoplasmic reticulum receptors in skeletal muscle. The review presents an overview of the history and current knowledge of pathophysiology, genetics, clinical picture and treatment of MH, gives important information for anaesthesia practice, summarizes current means of pre-symptomatic testing and informs on the state of MH diagnostic world-wide and in the Czech Republic. |