Publication details

Snášenlivost a bezpečnost antipsychotik druhé a třetí generace

Title in English Safety and tolerability of second and third generation antipsychotics.


Year of publication 2005
Type Article in Periodical
Magazine / Source Česká a slovenská psychiatrie
MU Faculty or unit

Faculty of Medicine

Field Psychiatry, sexuology
Keywords second and third generation antipsychotics; extrapyramidal side effects; morbidity; mortality; prolongation of QT interval
Description At first the authors deal with new antipsychotics. In the centre of interest there are new antipsychotics, often referred to as atypical or antipsychotics of the second or third generation. The atypical antipsychotics carry less risk of EPS, however, they can cause other side effects. These can be a problem, because schizophrenic patientes have higher rate of morbidity and mortality from cardiovascular disease independent from trestment These side effects include weight gain, diagetes, hyperlipidemia and QT prolongation. The published data concerning this topic are summarized. Finally the data concerning the QZ prolongation in unselected population of hospitalised psychiatric patients at Brno psychiatric department are presented. The occurence (4.1% of patients)of abnormal QTc was lower than in the so-far availablew literature. This could be connected with the change of spectrum of antipsychotics used, the general trend to use lower doses of antipsychotics and prescribers increasing awareness about this phenomenon.
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