Publication details

Pulse cyclophosphamide for corticosteroid-refractory graft-versus-host disease.

Authors

MAYER Jiří KREJČÍ Marta DOUBEK M. POSPÍŠIL Z. BRYCHTOVÁ Yvona TOMIŠKA Miroslav RÁČIL Zdeněk

Year of publication 2005
Type Article in Periodical
Magazine / Source Bone Marrow Transplantation
MU Faculty or unit

Faculty of Medicine

Citation
Keywords acute GVHD; cyclophosphamide; immunosuppression
Description Corticosteroid-resistant GVHD is difficult to manage and is associated with high morbidity and mortality. Cyclophosphamide (Cy) is an established immunosuppressive and cytotoxic drug widely used as part of pretransplant conditioning regimens. In a retrospective study of 15 patients who had not responded to corticosteroids (nine with acute GVHD, three with GVHD after donor leukocyte infusion, and three progressive chronic GVHD), pulse Cy at a median dose of 1 g/m(2) was very effective in the treatment of skin (100% response), liver (70% response), and the oral cavity (100% response). Severe intestinal GVHD responded poorly. The toxicity pro. le was acceptable, with manageable, short-term myelosuppression in some patients. The risk of opportunistic infections, mixed chimerism, relapses, or post-transplant lymphoproliferative disease was not increased. Overall survival was 57%, with median and maximum follow-up of 9 and 37 months, respectively. The cost of the drug was negligible, especially when compared to monoclonal antibodies. Pulse Cy requires further investigation in corticosteroid-resistant GVHD.

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