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Pulse cyclophosphamide for corticosteroid-refractory graft-versus-host disease.

Název česky Puls cyklofosfamidu na kortikoid-rezistentní GVHD.
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MAYER Jiří KREJČÍ Marta DOUBEK M. POSPÍŠIL Z. BRYCHTOVÁ Yvona TOMIŠKA Miroslav RÁČIL Zdeněk

Rok publikování 2005
Druh Článek v odborném periodiku
Časopis / Zdroj Bone Marrow Transplantation
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Klíčová slova acute GVHD; cyclophosphamide; immunosuppression
Popis Corticosteroid-resistant GVHD is difficult to manage and is associated with high morbidity and mortality. Cyclophosphamide (Cy) is an established immunosuppressive and cytotoxic drug widely used as part of pretransplant conditioning regimens. In a retrospective study of 15 patients who had not responded to corticosteroids (nine with acute GVHD, three with GVHD after donor leukocyte infusion, and three progressive chronic GVHD), pulse Cy at a median dose of 1 g/m(2) was very effective in the treatment of skin (100% response), liver (70% response), and the oral cavity (100% response). Severe intestinal GVHD responded poorly. The toxicity pro. le was acceptable, with manageable, short-term myelosuppression in some patients. The risk of opportunistic infections, mixed chimerism, relapses, or post-transplant lymphoproliferative disease was not increased. Overall survival was 57%, with median and maximum follow-up of 9 and 37 months, respectively. The cost of the drug was negligible, especially when compared to monoclonal antibodies. Pulse Cy requires further investigation in corticosteroid-resistant GVHD.

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