Porovnání standardních prognostických faktorů u pacientů s mnohočetným myelomem s delecí 13q14 stanovenou metodou interfázní fluorescenční in situ hybridizace na separovaných a neseparovaných buňkách kostní dřeně.

• Title in English: Comparison of Standard Prognostic Factors with the deletion of 13q14 Detected by Interphase Fluorescence in Situ Hybridization on Separated and Unseparated Bone Marrow Cells in Multiple Myeloma
• Authors: SMEJKALOVÁ Jana; VRANOVÁ Vladimíra; OLTOVÁ Alexandra; KUGLÍK Petr; FILKOVÁ Hana; HEINIGOVÁ Jana; KOVÁŘOVÁ Lucie; ADAM Zdeněk; KREJČÍ Marta; POUR Luděk; BÜCHLER Tomáš; SVOBODNÍK Adam; VOSTREJŠOVÁ Silvie; KALÁBOVÁ Vladka; VORLÍČEK Jiří; PENKA Miroslav; HÁJEK Roman
• Year of publication: 2005
• Type: Article in Periodical
• Magazine / Source: Časopis Lékařů českých
• MU Faculty or unit: Faculty of Science
• Field: Genetics and molecular biology
• Keywords: multiple myeloma; magnetic-activated cell separation; interphase fluorescence in situ hybridization; 13q14 deletion; prognostic factors
• Description: Comparison of standard prognostic factors with the deletion of 13q14 detected by interphase fluorescence in situ hybridization on separated and unseparated bone marrow cells in multiple myeloma. Our results confirm that immunomagnetic selection of CD138+ cells increase the probability of detection of the 13q14 deletion in bone marrow samples using interphase fluorescent in situ hybridization technique.

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