Změny difúzních parametrů mozku potkana během epileptiformní neuronální aktivity navozené pilokarpinem

• Title in English: Changes of diffusion parameters of rat brain during pilocarpine-induced epilepsy
• Authors: ŠLAIS Karel; VOŘÍŠEK Ivan; DMYTRENKO Lesia; SYKOVÁ Eva
• Year of publication: 2007
• Type: Conference abstract
• MU Faculty or unit: Faculty of Medicine
• Description: The objective of the present work was to determine the diffusion parameters in the brain cortex of adult rats after pilocarpine-induced seizures - an experimental model widely used to study the pathophysiology of epilepsy. We conclude that pathologically increased neuronal activity during pilocarpine-induced seizures causes cell swelling followed by a reduction in the ECS volume fraction, a conclusion supported by the MR results (ADCw decrease).

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