Blocking CB1 receptors - a promising approach for treatment of drug dependence ?

• Authors: LANDA Leoš; ŠLAIS Karel; ŠULCOVÁ Alexandra
• Year of publication: 2007
• Type: Article in Proceedings
• Conference: Addiction and Eating Disorders Neurobiology and Comorbidities
• MU Faculty or unit: Faculty of Medicine
• Field: Pharmacology and pharmaceutical chemistry
• Keywords: cannabinoids; CB1 receptor; open field test
• Description: In the group pre-treated with methamphetamine only, behavioural sensitization occurred, whereas in the group pre-treated with the combination of methamphetamine and selective CB1 receptor antagonist AM 251 behavioural responses were suppressed and locomotor activity in the open field was significantly reduced.

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