Modulation of steroidogenic gene expression and hormone production of H295R cells by pharmaceuticals and other environmentally active compounds

• Authors: GRACIA Tannia; HILSCHEROVÁ Klára; JONES P.D.; NEWSTED J.L.; HIGLEY E.B.; ZHANG X.; HECKER Marcus; MURPHY M.; YU R.M.K.; LAM P.K.S.; WU R.S.S.; GIESY John P.
• Year of publication: 2007
• Type: Article in Periodical
• Magazine / Source: Toxicology and applied pharmacology
• MU Faculty or unit: Faculty of Science
• Field: Environment influence on health
• Keywords: steroidogenesis; in vitro; hormone production; pharmaceuticals; environmental pollutants; steroidogenic gene expression
• Description: The study has shown effects of some commonly used pharmaceuticals with a potential to enter the environment on the hormone production and expression of the key enzymes in steeroidogenesis, documenting thus side effects of these widely used drugs. The tests with binary mixtures have shown different extent of joint action in the mixtures.

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