Publication details

The association of interleukin-6 (IL-6) haplotypes with plaque-induced gingivitis in children

Authors

IZAKOVIČOVÁ HOLLÁ Lydie MUSILOVÁ Kristína VOKURKA Jan KLAPUŠOVÁ Lucie PANTŮČKOVÁ Pavla KUKLETOVÁ Martina KUKLA Lubomír ZNOJIL Vladimír

Year of publication 2008
Type Article in Periodical
Magazine / Source Acta Odontologica Scandinavica
MU Faculty or unit

Faculty of Medicine

Citation
Field ORL, ophthalmology, stomatology
Keywords cytokine; gene; gingivitis; PCR; polymorphism
Description The proinflammatory cytokine interleukin-6 (IL-6) is a key regulator of the host response to microbial infection and major modulator of extracellular matrix catabolism and bone resorption. The aim of this case-control study was to test differences between children with and without gingivitis in distribution of IL-6 alleles at positions -174, -572, and -597 and their haplotypes. Our results indicate that the three promoter polymorphisms in the IL-6 gene act in a cooperative fashion and suggest that IL-6 haplotypes could play a role in the pathogenesis of gingivitis in Caucasian children.
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