Publication details

Use of quantitative model to assess the fractional area of t-tubular membrane in ventricular cardiomyocyte



Year of publication 2007
Type Article in Proceedings
Conference Engineering Mechanics 2007
MU Faculty or unit

Faculty of Medicine

Field Biophysics
Keywords cardiac cell; transverse-axial tubular system; tubular membrane area; quantitative modelling
Description The transverse (t-) tubules of cardiac ventricular myocytes create a complex network of membrane invaginations. Many of the key proteins involved in excitation-contraction coupling appear to be located predominantly at the t-tubule membrane. Despite their importance, the fraction of cell membrane within the t-tubules remains unclear: for example, measurement of cell capacitance following detubulation in rat cardiomyocytes suggests 32%, whereas optical measurements suggest up to 65%. We have therefore investigated the factors that may account for this discrepancy. Calculation of the combinations of t-tubule radius, length and density that produce t-tubular membrane fractions of 32% or 56% suggest that the true fraction is at the upper end of this range.
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