Fading of the inhibition of CYP2D6 after paroxetine treatment discontinuation

• Authors: ŽOURKOVÁ Alexandra; JUŘICA Jan; MCCASKEY HADAŠOVÁ Eva; PULKRÁBKOVÁ Lucie
• Year of publication: 2008
• Type: Article in Periodical
• Magazine / Source: European Neuropsychopharmacology
• MU Faculty or unit: Faculty of Medicine
• Field: Psychiatry, sexuology
• Keywords: disinhibition; CYP2D6; paroxetine; poor metaboliser; phenotype; genotype
• Description: The study unswers an important question: how long persists the inhibition after paroxetine treatment? The inhibition of CYP2D6 could exclude any substrates of CYP2D6 from the therapy. 4 weeks period seem to be sufficient for restoration of metabolic activity of CYP2D6.

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