Methamphetamine behavioural senistization in rodents: interactions with selected drugs and gender.

• Authors: ŠULCOVÁ Alexandra; KUČEROVÁ Jana; LANDA Leoš; PISTOVČÁKOVÁ Jana; NOVÁKOVÁ Jana; VRŠKOVÁ Dagmar
• Year of publication: 2008
• Type: Article in Periodical
• Magazine / Source: Adiktologie
• MU Faculty or unit: Faculty of Arts
• Field: Pharmacology and pharmaceutical chemistry
• Keywords: methamphetamine; MDMA; morphine
• Description: Different behavioural rodent models (rat i.v. drug self-administration, mouse agonistic behaviour, open field test,) were used. Behavioural sensitization to metamphetamine was ocnfirmed after repeated pretreatment with methpahetmaine itself but also after MDMA, morphine and cannabinoid CB1 receptor agonist. A higher rewarding effect of methamphetamine was noted in the sensitized animals with estrus-like conditions and attenuated by estrogen deprivation.

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