Methamphetamine behavioural senistization in rodents: interactions with selected drugs and gender.
|Year of publication||2008|
|Type||Article in Periodical|
|Magazine / Source||Adiktologie|
|MU Faculty or unit|
|Field||Pharmacology and pharmaceutical chemistry|
|Keywords||methamphetamine; MDMA; morphine|
|Description||Different behavioural rodent models (rat i.v. drug self-administration, mouse agonistic behaviour, open field test,) were used. Behavioural sensitization to metamphetamine was ocnfirmed after repeated pretreatment with methpahetmaine itself but also after MDMA, morphine and cannabinoid CB1 receptor agonist. A higher rewarding effect of methamphetamine was noted in the sensitized animals with estrus-like conditions and attenuated by estrogen deprivation.|