Publication details
Constant current chronopotentiometry and voltammetry of native and denatured serum albumin at mercury and carbon electrodes
| Authors | |
|---|---|
| Year of publication | 2008 |
| Type | Article in Periodical |
| Magazine / Source | Electroanalysis |
| MU Faculty or unit | |
| Citation | |
| Field | Electrochemistry |
| Keywords | chronopotentiometry; voltammetry; albumin |
| Description | Constant current chronopotentiometric peak H at mercury electrodes was recently shown as a sensitive tool for global and local changes in protein conformation. Large differences between the heights of peak H of native (hBSAnat) and denatured BSA (hBSAden) were observed. The ratio hBSAden/hBSAnat increased with more negative stripping current suggesting that the rate of potential change is important for discrimination between native and denatured BSA. Voltammetric peaks of BSA were less well developed and BSAden/BSAnat was much smaller. It was not possible to discriminate BSAden and BSAnat using carbon electrodes. |
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