Publication details

C-13 Relaxation Studies of RNA Dynamics: Challenges and Solutions



Year of publication 2008
Type Article in Proceedings
Conference XXIII International Conference on Magnetic Resonance in Biological Systems
MU Faculty or unit

Faculty of Science

Field Biophysics
Keywords NMR; nucleic acids;RNA;dynamics
Description NMR relaxation experiments provide a way of monitoring molecular dynamics with atomic resolution. However, the measurement of 13C relaxation rates and their interpretation faces serious challenges. We have modified the Model-Free procedure to explicitly take into account asymmetric character of the carbon chemical shielding tensors and the effect of neighboring nuclei. The extended version of the Model-Free analysis generally produces more realistic values of the order parameter.
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