Publication details
Vliv behaviorální senzitizace a pohlaví na metamfetaminovou závislost u člověka a ve zvířecím modelu
| Title in English | Behavioural sensitization and gender differences in conditions of methamphetamine abuse in humal and animal models |
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| Authors | |
| Year of publication | 2008 |
| Type | Article in Periodical |
| Magazine / Source | Alkoholismus a drogové závislosti |
| MU Faculty or unit | |
| Citation | |
| Field | Pharmacology and pharmaceutical chemistry |
| Keywords | behavioral sensitization; methamphetamine; gender differences |
| Description | Behavioural sensitization is known to be developed after repeated administration of the drugs of abuse as an outcome of neuroadaptation increasing responses of the organism. Therefore even a small dose administered during abstaining period may lead to relapse of addiction. Methamphetamine is one of the most frequently abused substances and occurrence of behavioural sensitization to the drug is repeatedly proven in both animal models and clinical studies. This review summarizes the information about pharmacological mechanisms of methamphetamine, behavioural sensitization and gender differences in the reactivity to the drug and possible approaches to novel drug abuse treatment. |
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