Detekce nebalancovaných chromosomových změn u pacientů s mnohočetným myelomem pomocí techniky komparativní genomové hybridizace (CGH)

• Title in English: Detection of imbalanced chromosomal changes in multiple myeloma patients using comparative genomic hybridization (CGH)
• Authors: ZAORALOVÁ Romana; VRANOVÁ Vladimíra; KUGLÍK Petr
• Year of publication: 2008
• Type: Article in Periodical
• Magazine / Source: Klinická onkologie, Supplementum
• MU Faculty or unit: Faculty of Medicine
• Field: Genetics and molecular biology
• Keywords: Multiple myeloma; cytogenetics; chromosomal aberrations; FISH; comparative genomic hybridization
• Description: We show an example of use the classic CGH (comparative genomic hybridization) and HR-CGH (comparative genomic hybridization with higher resolution) in five multiple myeloma patients. The aim of the experiments was to complete the results of FISH analyses of other imbalanced chromosomal abnormalities. The other aim was to compare these methods in detecting chromosomal changes in samples with different infiltration.

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