Publication details
Immune regulation defects in high-risk relatives of children with type 1 diabetes
| Authors | |
|---|---|
| Year of publication | 2008 |
| Type | Article in Proceedings |
| Conference | ACTA PAEDIATRICA |
| MU Faculty or unit | |
| Citation | |
| Field | Immunology |
| Keywords | type 1 diabetes; high-risk relatives; T-regulatory cells |
| Description | Abnormalities in CD4+CD25+ regulatory T cells (Treg) may contribute to type 1 diabetes (T1D) development. First-degree relatives of T1D patients are at increased risk especially when they carry certain HLA II haplotypes. The defective function of Treg was performed by significantly higher activation of diabetogeneic T cells in high-risk relatives of T1D patients compared to healthy controls. |