Publication details
Versatile templates for the development of novel kinase inhibitors: Discovery of novel CDK inhibitors
| Authors | |
|---|---|
| Year of publication | 2007 |
| Type | Article in Periodical |
| Magazine / Source | Bioorganic & Medicinal Chemistry Letters |
| MU Faculty or unit | |
| Citation | |
| Field | Pharmacology and pharmaceutical chemistry |
| Keywords | kinases; template; CDK2 |
| Description | A series of four bicyclic cores were prepared and evaluated and cyclin-dependent kinase-2 (CDK2) inhibitors. From the in vitro and cell-based analysis, the pyrazolo[1,5-a]pyrimidine core (represented by 9) emerged as the superior for further elaboration in the identification of novel CDK2 inhibitors. |