Publication details
Novel 4-cyano, 4-amino, and 4-aminomethyl Derivatives of Pyrazolo[1,5-a]pyridines, Pyrazolo[1,5-c]pyrimidines and 2-H-indazole Compounds and 5-cyano, 5-amino, and 5-aminomethyl Derivatives of Imidazo[1,2-a]pyridines, and Imidazo[1,5-a]pyrazines Compounds
| Authors | |
|---|---|
| Year of publication | 2007 |
| Type | Patent |
| MU Faculty or unit | |
| Publisher | World Intellectula Property Organization |
| State | United States |
| Patent's number | WO 2007/032936 A2 |
| Description | The invention provides a class of bicyclic heterocyclic compds. of formulas I, II, and III as inhibitors of cyclin dependent kinases, methods of prepg. such compds., pharmaceutical compns. contg. one or more such compds., methods of prepg. pharmaceutical formulations comprising one or more such compds., and methods of treatment, prevention, inhibition, or amelioration of one or more diseases assocd. with the CDKs using such compds. or pharmaceutical compns. Compds. of formulas I, II, and III wherein X is C or N; Y is CH, NH2, and CH2NH2; R1 is H, halo, NH2, (un)substituted alkyl, alkenyl, (hetero)aryl, CF3, etc.; R2 is H, halo, NH2 and derivs., CO2H and derivs., CONH2 and derivs., alkyl, alkenyl, alkynyl, cycloalkyl, (hetero)aryl, etc.; R3 is halo, CN, amino, alkylamino, cycloalkylamino, arylakylamino, hydroxyalkylamino, etc.; R4 is H, halo, CN and alkyl; are claimed. Example compd. IV was prepd. by cyanation of 5-bromo-6-phenyl-8-(pyridin-3-ylmethylamino)imidazo[1,5-a]pyrazine with zinc cyanide. All the invention compds. were evaluated for their CDK inhibitory activity. |