Thiamine levels and transketolase genetic variants as modifiers of progression of diabetic nephropathy

• Authors: PÁCAL Lukáš; TOMANDL Josef; TANHÄUSEROVÁ Veronika; TOMANDLOVÁ Marie; KRUSOVÁ Darja; SVOJANOVSKÝ Jan; ŠTĚPÁNKOVÁ Soňa; BĚLOBRÁDKOVÁ Jana; OLŠOVSKÝ Jindřich; KAŇKOVÁ Kateřina
• Year of publication: 2009
• Type: Conference abstract
• MU Faculty or unit: Faculty of Medicine
• Description: The specific aims of the study were (i) quantification of plasma and erythrocyte levels of thiamines (Th, ThMP, ThDP), (ii) haplotype-based association study of DN with TKT variability, (iii) genotype vs. phenotype correlation of TKT variability and enzyme erythrocyte activity and (iv) evaluation of prognostic value of those biochemical and genetic parameters for the progression of DN.

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