Publication details
Matrix metalloproteinase-9 and matrix metalloproteinase-2 as biomarkers of various courses in multiple sclerosis
| Authors | |
|---|---|
| Year of publication | 2009 |
| Type | Article in Periodical |
| Magazine / Source | Multiple sclerosis |
| MU Faculty or unit | |
| Citation | |
| Field | Neurology, neurosurgery, neurosciences |
| Keywords | immunology; matrix metalloproteinase 2; matrix metalloproteinase 9; multiple sclerosis; |
| Description | The goal was to determine the serum levels of matrix metalloproteinase-9(MMP-9)matrix metalloproteinase-2(MMP-2)and their tissue inhibitors(TIMP-1)and(TIMP-2)and to investigate their possible relations to type,disability,and severity of MS.87 patients with definite MS according to the McDonald kriteria and 50 healthy controls were enrolled.Their clinical status was evaluated with the Expanded Disability Status Scale.Serum levels were analyzed by enzyme-linked immunoassay.A significant elevation in MMP-9 serum levels and in the MMP-9/TIMP-1 ratio was found in the whole MS group(P<0.001),in the relapsing-remitting MS(RRMS)(P<0.001)and secondaryprogressive MS(SPMS)(P <0.001)groups when compared with the controls.A significant elevation in MMP-2serum levels and in the MMP-2/TIMP-2 ratio was observed in the primary progressive(P<0.001)and the SPMS(P<0.002)groups when compared with the RRMS group,and this increase was also associated with the disability(P < 0.001)and severity(P<0.05). |