Publication details
Monitoring of immunosuppressive cytokines in glioblastoma
| Authors | |
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| Year of publication | 2009 |
| Type | Conference abstract |
| MU Faculty or unit | |
| Citation | |
| Description | Multiform glioblastoma (GBM) is by far the most malignant form of primary brain tumors with limited therapeutic options. Median survival is estimated approximately to 12 months with less than 25% of patients surviving up to 2 years after diagnosis and less than 10% surviving up to 5 years. Despite great efforts, standard therapy based on neurosurgery, chemo- and radiotherapy fails. GBM tumors often avoid immune surveillance by inhibition of infiltrating immune cells by paracrine signaling. Among these factors, proteins of TGFb family are highly involved. In this study, we focused on expression of TGFbeta1-3, BMP-7, BMP-9, GDF-15 and other growth factors, immunomodulators or tumor-associated genes in samples of patients newly diagnosed for GBM. These samples were analyzed by quantitative PCR and normalized either to control, healthy brain tissue, or non-malignant disease. We found significant change of expression several genes of TGFbeta family that correlates with development of malignant disease. This study can contribute to better understanding of the strong immune suppressive phenomenon in GBM patients. This study is supported by IGA9875-4 of Ministry of Health of the Czech Republic. |
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