Unusual Interstrand Pt(S,S-diaminocyclohexane)-GG Crosslink Formed by Rearrangement of a Classical Intrastrand Crosslink Within a DNA Duplex

• Authors: KUBÍČEK Karel; MONNET Jordan; SCINTILLA Simone; KOPEČNÁ Jana; ARNESANO Fabio; TRANTÍREK Lukáš; CHOPARD Claude; NATILE Giovanni; KOZELKA Jiří
• Year of publication: 2010
• Type: Peer-reviewed scientific article
• Magazine / Source: Chemistry - An Asian Journal
• MU Faculty or unit: Faculty of Science
• web: http://dx.doi.org/10.1002/asia.200900655
• Field: Biophysics
• Keywords: DNA structures; interstrand crosslinks; molecular modeling; NMR spectroscopy; platinum
• Description: An unusual G6G11 interstrand crosslink is formed by spontaneous rearrangement of the canonical G5G6 intrastrand crosslink generated from the DNA duplex d(CCTTG5G6T7C8TC)-d(G11AGACCAAGG) and Pt(S,S-di-aminocyclohexane)2+ (the enantiomer of the antitumor drug oxaliplatin). The final product provides a rare example of intramolecular self-intercalation of DNA.

Related projects

• NMR study of interaction of cisplatined G/T mismatched DNA substrate with protein MutS
• Biofyzikální výzkum struktur a funkcí biomolekul