Publication details
Transactivation by temperature-dependent p53 mutants in yeast and human cells
| Authors | |
|---|---|
| Year of publication | 2010 |
| Type | Article in Periodical |
| Magazine / Source | Cell Cycle |
| MU Faculty or unit | |
| Citation | |
| Field | Genetics and molecular biology |
| Keywords | p53; FASAY; transactivation |
| Description | We analyzed transactivation of several p53-target genes by 23 temperature-dependent p53 mutants and stratified them into four functional groups. Seventeen mutants exhibited temperature-dependency and discriminative character in human and yeast cells. Our analysis showed that functional analysis of separated alleles in yeast is valuable tool for assessment of the human p53 status. |
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