Publication details

Generation of myeloma-specific T cells using dendritic cells loaded with MUC1- and hTERT- drived nonapeptides or myeloma cell apoptotic bodies

Authors

OČADLÍKOVÁ Darina KRYUKOV Fedor MOLLOVÁ Klára KOVÁŘOVÁ Lucie BUREŠOVÁ Ivana MATĚJKOVÁ Eva PENKA Miroslav BÜCHLER Tomáš HÁJEK Roman MICHÁLEK Jaroslav

Year of publication 2010
Type Article in Periodical
Magazine / Source Neoplasma
MU Faculty or unit

Faculty of Medicine

Citation
Field Oncology and hematology
Keywords multiple myeloma; dendritic cells; immunotherapy; hTERT; MUC1; apoptotic bodies
Description The aim of our study was to generate myeloma-specific cytotoxic T lymphocytes in vitro using dendritic cells loaded with peptide antigens or apoptotic bodies. We present a method for the priming and expansion of myeloma-specific T lymphocytes using dendritic cells loaded with different types of tumor antigens. Cytotoxic T lymphocytes and/or activated dendritic cells generated by the described methods can be applied for cellular immunotherapy against multiple myeloma and other malignancies.
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