Association of FcRn expression with lung abnormalities and IVIG catabolism in patients with common variable immunodeficiency

• Authors: FREIBERGER Tomáš; GRODECKÁ Lucie; RAVČUKOVÁ Barbora; KUŘECOVÁ Barbora; POSTRÁNECKÁ Věra; VLČEK Jiří; JARKOVSKÝ Jiří; THON Vojtěch; LITZMAN Jiří
• Year of publication: 2010
• Type: Article in Periodical
• Magazine / Source: CLINICAL IMMUNOLOGY
• MU Faculty or unit: Faculty of Medicine
• Doi: http://dx.doi.org/10.1016/j.clim.2010.05.006
• Field: Genetics and molecular biology
• Keywords: Neonatal Fc receptor; FcRn; Common variable immunodeficiency; Lung disease; IVIG
• Description: Patients with generalized bronchiectasis and fibrosis had lower levels of FCRN mRNA compared to patients without these complications. Moreover, FCRN mRNA levels correlated negatively with the extent of bronchiectasis and the rate of IgG decline after infusion of IVIG.Our results showed that FcRn might play a role in the development of lung structural abnormalities and in the catabolism of IVIG in patients with CVID.