Different effect of two synthetic coumarin-stilbene hybrid compounds on phagocyte activity

• Authors: DRÁBIKOVÁ Katarína; PEREČKO Tomáš; NOSÁL Radomír; RAČKOVÁ Lucia; AMBROŽOVÁ Gabriela; LOJEK Antonín; ŠMIDRKAL Jan; HARMATHA Juraj; JANČINOVÁ Viera
• Year of publication: 2010
• Type: Article in Periodical
• Magazine / Source: Neuroendocrinology Letters
• MU Faculty or unit: Faculty of Science
• Web: http://www.ncbi.nlm.nih.gov/pubmed?term=Different%20effect%20of%20two%20synthetic%20coumarin-stilbene%20hybrid%20compounds%20on%20phagocyte%20activity
• Field: Pharmacology and pharmaceutical chemistry
• Keywords: human neutrophils; murine macrophages RAW 264.7; reactive oxygen species; nitric oxide; phenylcoumarins with a resveratrol moiety
• Description: Synthetic phenylcoumarin derivatives HHC (7-hydroxy-3-(4-hydroxyphenyl) coumarin) and HHDC (7-hydroxy-3-(4-hydroxyphenyl)-3,4-dihydrocoumarin) can affect ROS generation in human neutrophils and NO production by RAW 264.7 macrophages. The obtained results highlighted the different effects of HHC and HHDC on fagocyte functions, which might be due to their diverse free radical scavenging properties and lipophilicity features.