Publication details

Treatment of Deep Vein Thrombosis with Continuous IV Infusion of LMWH: A Retrospective Study in 32 Children

Authors

FIAMOLI Veronika BLATNÝ Jan ZAPLETAL Ondřej KÖHLEROVÁ Světlana JANOUŠOVÁ Eva

Year of publication 2011
Type Article in Periodical
Magazine / Source Thrombosis
MU Faculty or unit

Faculty of Medicine

Citation
Doi http://dx.doi.org/10.1155/2011/981497
Field Other specializations of internal medicine
Keywords deep vein thrombosis; LMWH; risk of thrombosis; antiXa
Description Thirty-two consecutive children aged 0–18 years with VTE treated with LMWH administered as a continuous infusion (CI) were identified at the Children’s University Hospital Brno. The treatment led to at least partial resolution of the thrombus within two weeks in 85% of patients. There were no adverse events or increased bleeding reported in any patients. No recurrences were observed during a followup period of 6 months. Although continuous infusion should not replace subcutaneous (SC) administration of LMWH, CI appeared to be safe and efficient and may provide an alternate method of administering LMWH in a subset of the paediatric population where SC administration may not be feasible. Further prospective studies are needed to support the promising findings of our pilot clinical observation.

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