Publication details
Mezilaboratorní studie stanovení volných monoklonálních lehkých řetězců imunoglobulinů
| Title in English | Comparison of results of monoclonal free immunoglobulin light chains quantification in the serum in clinical laboratories in the Czech Republic |
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| Authors | |
| Year of publication | 2010 |
| Type | Article in Periodical |
| Magazine / Source | Klinická biochemie a matabolismus |
| MU Faculty or unit | |
| Citation | |
| Field | Oncology and hematology |
| Keywords | Interlaboratory comparison; Monoclonal free light chains; Monoclonal gammopathy; Multiple myeloma |
| Description | Free monoclonal immunoglobulin light chains (FLC) quantification is recommended for diagnosis assessment and monitoring therapy for patients with monoclonal gammopathy. But there are numerous uncertainties regarding the detection, interpretation and FLC quantification. Our interlaboratory study showed that kappa/lambda ratio is strongly influenced by measurement errors and therefore we recommended the preferential use of FLC concentration values. Unified protocols are needed to minimise interlaboratory variability introduced by manual dilution or volume augmentation of clinical sample. |
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