Publication details

Receptor-Mediated Endocytosis of Nanoparticles of Various Shapes



Year of publication 2011
Type Article in Periodical
Magazine / Source Nano Lett
MU Faculty or unit

Central European Institute of Technology

Field Physical chemistry and theoretical chemistry
Keywords Effective uptake; passive endocytosis; phospholipid membrane; nanoparticle shape; molecular dynamics
Attached files
Description Cellular uptake through endocytosis is crucial for drug delivery and nanomedicine. However, the conditions under which passive endocytosis (i.e., not ATP driven) takes place are not well understood. We report MD simulations of the passive uptake of ligand-coated nanoparticles with varying size, shape, coverage, and membrane-binding strength. We find that the efficiency of passive endocytosis is higher for spherocylindrical particles than for spheres and that endocytosis is suppressed for particles with sharp edges.

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