Publication details
Receptor-Mediated Endocytosis of Nanoparticles of Various Shapes
| Authors | |
|---|---|
| Year of publication | 2011 |
| Type | Article in Periodical |
| Magazine / Source | Nano Lett |
| MU Faculty or unit | |
| Citation | |
| Doi | http://dx.doi.org/10.1021/nl2030213 |
| Field | Physical chemistry and theoretical chemistry |
| Keywords | Effective uptake; passive endocytosis; phospholipid membrane; nanoparticle shape; molecular dynamics |
| Attached files | |
| Description | Cellular uptake through endocytosis is crucial for drug delivery and nanomedicine. However, the conditions under which passive endocytosis (i.e., not ATP driven) takes place are not well understood. We report MD simulations of the passive uptake of ligand-coated nanoparticles with varying size, shape, coverage, and membrane-binding strength. We find that the efficiency of passive endocytosis is higher for spherocylindrical particles than for spheres and that endocytosis is suppressed for particles with sharp edges. |