Publication details

Paramutation of tobacco transgenes by small RNA-mediated transcriptional gene silencing

Authors

CRHÁK KHAITOVÁ Lucie FOJTOVÁ Miloslava KŘÍŽOVÁ Kateřina LUNEROVÁ Jana FULNEČEK Jaroslav DEPICKER Anna KOVAŘÍK Aleš

Year of publication 2011
Type Article in Periodical
Magazine / Source Epigenetics
MU Faculty or unit

Central European Institute of Technology

Citation
Doi http://dx.doi.org/10.4161/epi.6.5.15764
Field Genetics and molecular biology
Keywords transcriptional gene silencing; transgene epialleles; DNA methylation; small RNA
Description It has been well established that trans-acting small RNAs guide promoter methylation leading to its inactivation and gene silencing at the transcriptional level (TGS).These features contrast with a non-methylated single copy transgenic locus that required several generations of contact with RNA silencing molecules to become imprinted in a stable epiallele.
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