Paramutation of tobacco transgenes by small RNA-mediated transcriptional gene silencing

• Authors: CRHÁK KHAITOVÁ Lucie; FOJTOVÁ Miloslava; KŘÍŽOVÁ Kateřina; LUNEROVÁ Jana; FULNEČEK Jaroslav; DEPICKER Anna; KOVAŘÍK Aleš
• Year of publication: 2011
• Type: Article in Periodical
• Magazine / Source: Epigenetics
• MU Faculty or unit: Central European Institute of Technology
• Doi: http://dx.doi.org/10.4161/epi.6.5.15764
• Field: Genetics and molecular biology
• Keywords: transcriptional gene silencing; transgene epialleles; DNA methylation; small RNA
• Description: It has been well established that trans-acting small RNAs guide promoter methylation leading to its inactivation and gene silencing at the transcriptional level (TGS).These features contrast with a non-methylated single copy transgenic locus that required several generations of contact with RNA silencing molecules to become imprinted in a stable epiallele.

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