Publication details

Androgen Depletion Induces Senescence in Prostate Cancer Cells through Down-regulation of Skp2

Authors

PERNICOVÁ Zuzana SLÁBÁKOVÁ Eva KHARAISHVILI Gvantsa BOUCHAL Jan KRÁL Milan KUNICKÁ Zuzana MACHALA Miroslav KOZUBÍK Alois SOUČEK Karel

Year of publication 2011
Type Article in Periodical
Magazine / Source Neoplasia
MU Faculty or unit

Central European Institute of Technology

Citation
Web http://www.neoplasia.com/pdf/manuscript/v13i06/neo11182.pdf
Doi http://dx.doi.org/10.1593/neo.11182
Field Genetics and molecular biology
Keywords CELLULAR SENESCENCE; IN-VIVO; DEPRIVATION THERAPY; SECRETORY PHENOTYPE; EPITHELIAL-CELLS; TUMORIGENESIS; FIBROBLASTS; EXPRESSION; GROWTH; PROLIFERATION
Description Although the induction of senescence in cancer cells is a potent mechanism of tumor suppression, senescent cells remain metabolically active and may secrete a broad spectrum of factors that promote tumorigenicity in neighboring malignant cells.We propose that ADT may contribute to the development of androgen-independent prostate cancer through modulation of the tissue microenvironment by senescent cells.
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