Publication details

Mutace p53 - krok na cestě k nádoru

Title in English p53 mutation - step on the way to tumor


Year of publication 2011
Type Article in Proceedings
Conference Informační listy Genetické společnosti Gregora Mendela
MU Faculty or unit

Faculty of Science

Field Genetics and molecular biology
Keywords tumor; tumor suppressor p53; mutation
Description p53 is a key tumor suppressor. It protects cell against oncogenic transformation in many ways. The loss of the tumor suppressor p53 function itself moves cells strongly toward the tumor phenotype. In addition, many p53 protein variants, in consequence of mutation, gain other – oncogenic properties which move cells even further toward malignant phenotype. Thus p53 mutations undoubtedly represent cardinal step toward a tumor.
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