Does repetitive transcranial magnetic stimulation have a positive effect on working memory and neuronal activation in treatment of negative symptoms of schizophrenia?

• Authors: PŘIKRYL Radovan; MIKL Michal; PŘIKRYLOVÁ KUČEROVÁ Hana; USTOHAL Libor; KAŠPÁREK Tomáš; MAREČEK Radek; VRZALOVÁ Michaela; ČEŠKOVÁ Eva; VANÍČEK Jiří
• Year of publication: 2012
• Type: Article in Periodical
• Magazine / Source: Neuroendocrinology Letters
• MU Faculty or unit: Central European Institute of Technology
• Web: http://www.ncbi.nlm.nih.gov/pubmed/22467118
• Field: Psychiatry, sexuology
• Keywords: cognitive functions; fMRI; neuronal activation; negative symptoms

Attached files

• NEL_rTMS_negSCH_fMRI_2012.pdf

• Description: Stimulation treatment led to a reduction of seriousness of negative schizophrenia symptoms in both comparative groups. However, mutual comparison of real (n=19) and sham (n=11) rTMS, respectively, has shown that the effect of real rTMS was statistically significantly higher compared with placebo stimulation. During stimulation treatment an improvement in working memory performance was also found. No statistically significant difference between the real and placebo sham rTMS, respectively, was established. The rate of neuronal activation did not change at all during rTMS treatment.

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• The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.
• Funkční mozkové koreláty související s léčbou negativních příznaků schizofrenie repetitivní transkraniální magnetickoustimulací