Publication details

Estimation of rate constants of drug binding to open channels of cardiac transient outward current



Year of publication 2012
Type Article in Periodical
Magazine / Source General Physiology and Biophysics
MU Faculty or unit

Faculty of Medicine

Field Physiology
Keywords Ito channel; Drug binding; Open state; Rate constants; Mathematical model
Description An improved approach to the evaluation of the rate constants of drugs binding to the open channel underlying the transient outward potassium current Ito, is described. It is based on an analysis of a quantitative model formulated by a set of twelve differential equations. The rate constants are calculated from the time constants resulting from an approximation of the time course of apparent inactivation of the recorded Ito by two exponentials in the absence and by three exponentials in the presence, of a blocking agent. The model study confirmed significantly higher accuracy in comparison with the existing electrophysiological method.
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