Publication details
Immunoregulatory T cells in multiple sclerosis and the effect of interferon beta and glatiramer acetate treatment on T cell subpopulations
| Authors | |
|---|---|
| Year of publication | 2012 |
| Type | Article in Periodical |
| Magazine / Source | Journal of the Neurological Sciences |
| MU Faculty or unit | |
| Citation | |
| Web | Full Text |
| Doi | http://dx.doi.org/10.1016/j.jns.2012.05.036 |
| Field | Neurology, neurosurgery, neurosciences |
| Keywords | central memory T cells; glatiramer acetate; interferon beta; multiple sclerosis; naive T cells; regulatory T cells |
| Description | The objective of this study was to evaluate T cells subpopulations among multiple sclerosis patients. We analyzed lymphocyte subpopulations in MS patients and healthy controls and studied the treatment effects of interferon beta and glatiramer acetate treatment on T cells subpopulations during first year of treatment in comparison with untreated patients. We observed a significant increase of effector T cells and decrease in regulatory T cells in MS patients compared to healthy controls. After glatiramer acetate and interferon beta therapy we observed a significant decrease in effector T cells and thus the restoration of imbalance in the immune system. |