doc. Mgr. Kamil Paruch, Ph.D.

2020

• The CHK1 inhibitor MU380 significantly increases the sensitivity of human docetaxel-resistant prostate cancer cells to gemcitabine through the induction of mitotic catastrophe

  DRÁPELA Stanislav KHIRSARIYA PrashantKumar VAN WEERDEN Wytske M FEDR Radek SUCHÁNKOVÁ Tereza BÍZOVA Diana ČERVENÝ Jan HAMPL Aleš PUHR Martin WATSON William R CULIG Zoran KREJČÍ Lumír PARUCH Kamil SOUČEK Karel

  Article in Periodical

  Molecular oncology, year: 2020, volume: 14, edition: 10, DOI

2019

• ATR-CHK1 signaling is active and targetable in quiescent CLL cells

  BOUDNÝ Miroslav KHIRSARIYA PrashantKumar BORSKÝ Marek BRYCHTOVÁ Yvona PARUCH Kamil TRBUŠEK Martin

  Conference abstract

  Year: 2019, type: Conference abstract

• CDK12 controls G1/S progression by regulating RNAPII processivity at core DNA replication genes

  CHIRACKAL MANAVALAN Anil Paul PILAŘOVÁ Květa KLUGE Michael BARTHOLOMEEUSEN Koen RÁJECKÝ Michal OPPELT Jan KHIRSARIYA PrashantKumar PARUCH Kamil KREJČÍ Lumír FRIEDEL Caroline C BLAŽEK Dalibor

  Article in Periodical

  EMBO reports, year: 2019, volume: 20, edition: 9, DOI

• Cílená inhibice kasein kinázy 1 v léčbě chronické lymfoidní leukémie.

  JANOVSKÁ Pavlína GREGOROVÁ M. NĚMEC Václav KHIRSARIYA PrashantKumar VERNER Jan KOHOUTEK J. POPPOVÁ Lucie PAVLOVÁ Šárka PLEVOVÁ Karla POSPÍŠILOVÁ Šárka PARUCH Kamil BRYJA Vítězslav

  Conference abstract

  Year: 2019, type: Conference abstract

• EU-OPENSCREEN: A Novel Collaborative Approach to Facilitate Chemical Biology

  BRENNECKE Philip RASINA Dace AUBI Oscar HERZOG Katja LANDSKRON Johannes CAUTAIN Bastien VICENTE Francisca QUINTANA Jordi MESTRES Jordi STECHMANN Bahne ELLINGER Bernhard BREA Jose KOLANOWSKI Jacek L. PILARSKI Radosław ORZAEZ Mar PINEDA-LUCENA Antonio LARAIA Luca NAMI Faranak ZIELENKIEWICZ Piotr PARUCH Kamil HANSEN Espen VON KRIES Jens P. NEUENSCHWANDER Martin SPECKER Edgar BARTŮNĚK Petr SIMOVA Šárka LESNIKOWSKI Zbigniew KRAUSS Stefan LEHTIO Lari BILITEWSKI Ursula BRONSTRUP Mark TASKEN Kjetil JIRGENSONS Aigars LICKERT Heiko CLAUSEN Mads H. ANDERSEN Jeanette H. VICENT Maria J. GENILLOUD Olga MARTINEZ Aurora NAZARE Marc FECKE Wolfgang GRIBBON Philip

  Article in Periodical

  SLAS DISCOVERY, year: 2019, volume: 24, edition: 3, DOI

• Furo[3,2-b]pyridine: A Privileged Scaffold for Highly Selective Kinase Inhibitors and Effective Modulators of the Hedgehog Pathway

  NĚMEC Václav HYLSOVÁ Michaela MAIER Lukáš FLEGEL Jana SIEVERS Sonja ZIEGLER Slava SCHRÖDER Martin BERGER Benedict-Tilman CHAIKUAD Apirat VALČÍKOVÁ Barbora ULDRIJAN Stjepan DRÁPELA Stanislav SOUČEK Karel WALDMANN Hebert KNAPP Stefan PARUCH Kamil

  Article in Periodical

  Angewandte Chemie International Edition, year: 2019, volume: 58, edition: 4, DOI

• CHK1 INHIBITION FACILITATES THE COOPERATIVE ANTICANCER ACTION OF PLATINUM-BASED DRUGS AND TRAIL

  KRKOŠKA Martin HERŮDKOVÁ Jarmila PARUCH Kamil NEVĚDĚLOVÁ Kateřina SOVA Petr HYRŠLOVÁ Alena

  Conference abstract

  Year: 2019, type: Conference abstract

• Inhibition of Chk1 enhances cooperative anticancer action of platinum-based drugs and TRAIL via activation of mitochondrial apoptotic pathway

  KRKOŠKA Martin HERŮDKOVÁ Jarmila PARUCH Kamil NEVĚDĚLOVÁ Kateřina SOVA Petr HYRŠLOVÁ VACULOVÁ Alena

  Conference abstract

  Year: 2019, type: Conference abstract

• Nanopatterning Glass Surface For Localization Of Embryonic Stem Cells

  HOVÁDKOVÁ Zuzana HRABOVSKÝ Milos VÁŇA Rostislav POSPÍŠIL Jakub JAROŠ Josef DAMBORSKÝ Jiří PARUCH Kamil HAMPL Aleš

  Conference abstract

  Year: 2019, type: Conference abstract

• Novel CHK1 inhibitor MU380 exhibits significant single-agent activity in TP53-mutated chronic lymphocytic leukemia cells

  BOUDNÝ Miroslav ZEMANOVÁ Jana KHIRSARIYA PrashantKumar BORSKÝ Marek VERNER Jan ČERNÁ Jana OLTOVÁ Alexandra ŠEDA Václav MRÁZ Marek JAROŠ Josef JAŠKOVÁ Zuzana ŠPUNAROVÁ Michaela BRYCHTOVÁ Yvona SOUČEK Karel DRÁPELA Stanislav KAŠPÁRKOVÁ Marie MAYER Jiří PARUCH Kamil TRBUŠEK Martin

  Article in Periodical

  Haematologica, year: 2019, volume: 104, edition: 12, DOI