doc. Mgr. Kamil Paruch, Ph.D.

2025

• Biology and pharmacological inhibition of homeodomain-interacting protein kinases

  ŠTEFEK Adam PARUCH Kamil

  Article in Periodical

  Frontiers in Chemical Biology, year: 2025, volume: 4, edition: February, DOI

• Discovery of new inhibitors of nuclease MRE11

  NIKULENKOV Fedor CARBAIN Benoit Jean-Pierre BISWAS Raktim HAVEL Štěpán PROCHÁZKOVÁ Jana SISÁKOVÁ Alexandra ZACPALOVÁ Magdaléna CHAVDAROVA Melita MARINI PALOMEQUE María Victoria VŠIANSKÝ Vít WEISOVÁ Veronika SLÁVIKOVÁ Kristína BIRADAR Dhanraj Omprakash KHIRSARIYA PrashantKumar VITEK Marco SEDLAK David BARTUNEK Petr DANIEL Lukáš BREZOVSKÝ Jan DAMBORSKÝ Jiří PARUCH Kamil KREJČÍ Lumír

  Article in Periodical

  European Journal of Medicinal Chemistry, year: 2025, volume: 285, edition: March, DOI

• Exploring the Regioselectivity of Diels–Alder Reactions of 2,6-Disubstituted Benzoquinones through DFT Calculations

  KALLA Erik SEMRÁD Hugo MAIER Lukáš PARUCH Kamil ZIPSE Hendrik MUNZAROVÁ Markéta

  Article in Periodical

  European Journal of Organic Chemistry, year: 2025, volume: 28, edition: 43, DOI

• Thieno[3,2-b]pyridine: Attractive scaffold for highly selective inhibitors of underexplored protein kinases with variable binding mode

  MARTÍN MOYANO Paula KUBINA Tadeáš PARUCH Štěpán Owen JAROŠKOVÁ Aneta NOVOTNÝ Jan SKOČKOVÁ Veronika OVESNÁ Petra SUCHÁNKOVÁ Tereza PROKOFEVA Polina KUSTER Bernhard ŠMÍDA Michal CHAIKUAD Apirat KRÄMER Andreas KNAPP Stefan SOUČEK Karel PARUCH Kamil

  Article in Periodical

  Angewandte Chemie International Edition, year: 2025, volume: 64, edition: 1, DOI

2024

• Discovery of Two Highly Selective Structurally Orthogonal Chemical Probes for Activin Receptor-like Kinases 1 and 2

  NĚMEC Václav REMEŠ Marek BEŇOVSKÝ Petr BÖCK Michael Christopher ŠRANKOVÁ Eliška WONG Jong Fu JULIEN Cros WILLIAMS Eleanor TSE Lap Hang SMIL David ENSAN Deeba ISAAC Methvin B AL-AWAR Rima GOMOLKOVÁ Regína URSACHI Vlad-Constantin FAFÍLEK Bohumil KAHOUNOVA Zuzana VICHOVA Rachel VACEK Ondrej BERGER Benedict-Tilman WELLS Carrow I CORONA Cesear R VASTA James D ROBERS Matthew B KREJČÍ Pavel SOUČEK Karel BULLOCK Alex N KNAPP Stefan PARUCH Kamil

  Article in Periodical

  Journal of Medicinal Chemistry, year: 2024, volume: 67, edition: 15, DOI

• IDENTIFICATION OF NOVEL CYTOKININS BY MOLECULAR DOCKING

  PUSHKAROVA Nadiia HENNELOVA Jana MARQUES Sérgio Manuel BEDNÁŘ David PARUCH Kamil AKAVARAM Naresh SPICHAL L. DAMBORSKÝ Jiří YEMETS A. HEJÁTKO Jan

  Conference abstract

  Year: 2024, type: Conference abstract

• Inhibition of Chk1 stimulates cytotoxic action of platinum-based drugs and TRAIL combination in human prostate cancer cells

  KRKOŠKA Martin PARUCH Kamil ŠOŠOLÍKOVÁ Tereza VÁZQUEZ-GÓMEZ Gerardo HERŮDKOVÁ Jarmila NOVOTNÝ Jan OVESNÁ Petra SOVA Petr HYRŠLOVÁ VACULOVÁ Alena

  Article in Periodical

  Biological Chemistry, year: 2024, volume: 405, edition: 6, DOI

• Nové látky, které inhibují CDK11, nalezené na základě sreeningu knihovny nízkomolekulárních látek a cílené syntézy

  BLAŽEK Dalibor PARUCH Kamil

  Outcomes put into operation (prototype, working sample)

  Year: 2024

• Novel casein kinase 1 alpha inhibitors for the treatment of resistant AML and solid tumors

  JANOVSKÁ Pavlína RADASZKIEWICZ Tomasz Witold PROCHAZKOVA P PRIŠTICOVÁ Ingrid PLEŠINGEROVÁ Hana ČULEN Martin ŠMÍDA Michal BUŠA Daniel LADUNGOVÁ Adriana MAIER Lukáš HAVEL Štěpán MAYER Jiří SCHEER A PARUCH Kamil BRYJA Vítězslav

  Conference abstract

  Year: 2024, type: Conference abstract

• Preklinický vývoj inhibitorů CDK11 - identifikace látek vhodných pro patentovou ochranu a komercializaci

  BLAŽEK Dalibor PARUCH Kamil

  Outcomes put into operation (prototype, working sample)

  Year: 2024