Ing. RNDr. Martin Marek, Ph.D., MBA

2023

• Advancing Enzyme's Stability and Catalytic Efficiency through Synergy of Force-Field Calculations, Evolutionary Analysis, and Machine Learning

  KUNKA Antonín MARQUES Sérgio Manuel HAVLÁSEK Martin VAŠINA Michal VELÁTOVÁ Nikola CENGELOVÁ Lucia KOVÁŘ David DAMBORSKÝ Jiří MAREK Martin BEDNÁŘ David PROKOP Zbyněk

  Article in Periodical

  ACS Catalysis, year: 2023, volume: 13, edition: 19, DOI

• Catalytic mechanism for Renilla-type luciferases

  SMITH Andrea TOUL Martin PLUSKAL Daniel BAATALLAH Racha GAGNOT Glwadys RANGEL PAMPLONA PIZARRO PINTO José Gaspar SANTANA Vinicius T. T. STUCHLÁ Markéta NEUGEBAUER Petr CHAIYEN Pimchai DAMBORSKÝ Jiří BEDNÁŘ David JANIN Yves L. L. PROKOP Zbyněk MAREK Martin

  Article in Periodical

  Nature Catalysis, year: 2023, volume: 6, edition: 1, DOI

• Deciphering Enzyme Mechanisms with Engineered Ancestors and Substrate Analogues

  GAO Tadeja DAMBORSKÝ Jiří JANIN Yves L. MAREK Martin

  Article in Periodical

  ChemCatChem, year: 2023, volume: 15, edition: 19, DOI

• Domino-like effect of C112R mutation on ApoE4 aggregation and its reduction by Alzheimer’s Disease drug candidate

  NEMERGUT Michal MARQUES Sérgio Manuel UHRÍK Lukáš VÁŇOVÁ Tereza NEZVEDOVÁ Markéta GADARA Darshak Chandulal JHA Durga TULIS Jan NOVÁKOVÁ Veronika PLANAS IGLESIAS Joan KUNKA Antonín LEGRAND Anthony Thomas P HŘÍBKOVÁ Hana POSPÍŠILOVÁ Veronika SEDMÍK Jiří RAŠKA Jan PROKOP Zbyněk DAMBORSKÝ Jiří BOHAČIAKOVÁ Dáša SPÁČIL Zdeněk HERNYCHOVÁ Lenka BEDNÁŘ David MAREK Martin

  Article in Periodical

  Molecular Neurodegeneration, year: 2023, volume: 18, edition: 1, DOI

• In cellulo and in vivo assays for compound testing cruzi

  GUERRA-SLOMPO Eloise Pavao PICCHI-CONSTANTE Gisele Fernanda Assine MAREK Martin ROMIER Christophe SIPPL Wolfgang ZANCHIN Nilson Ivo Tonin

  Article in Periodical

  STAR Protocols, year: 2023, volume: 4, edition: 1, DOI

• Multimeric structure of a subfamily III haloalkane dehalogenase-like enzyme solved by combination of cryo-EM and x-ray crystallography

  CHMELOVÁ Klaudia GAO Tadeja POLÁK Martin SMITH Andrea CROLL Tristan I. SHAIKH Tanvir R. ŠKAŘUPOVÁ Jana CHALOUPKOVÁ Radka DIEDERICHS Kay READ Randy J. DAMBORSKÝ Jiří NOVÁČEK Jiří MAREK Martin

  Article in Periodical

  Protein Science, year: 2023, volume: 32, edition: 10, DOI

2022

• Computer-aided engineering of staphylokinase toward enhanced affinity and selectivity for plasmin

  NIKITIN Dmitri MIČAN Jan TOUL Martin BEDNÁŘ David PEŠKOVÁ Michaela KITTOVÁ Patrícia THALEROVÁ Sandra VÍTEČEK Jan DAMBORSKÝ Jiří MIKULÍK Robert FLEISHMAN Sarel J. PROKOP Zbyněk MAREK Martin

  Article in Periodical

  Computational and Structural Biotechnology Journal, year: 2022, volume: 20, edition: May 2022, DOI

• Extended Mechanism of the Plasminogen Activator Staphylokinase Revealed by Global Kinetic Analysis: 1000-fold Higher Catalytic Activity than That of Clinically Used Alteplase

  TOUL Martin NIKITIN Dmitri MAREK Martin DAMBORSKÝ Jiří PROKOP Zbyněk

  Article in Periodical

  ACS Catalysis, year: 2022, volume: 12, edition: 7, DOI

• Hidden Potential of Highly Efficient and Widely Accessible Thrombolytic Staphylokinase

  TOUL Martin MIČAN Jan SLONKOVÁ Veronika NIKITIN Dmitri MAREK Martin BEDNÁŘ David DAMBORSKÝ Jiří PROKOP Zbyněk

  Article in Periodical

  Stroke, year: 2022, volume: 53, edition: 10, DOI

• Increased occurrence of Treponema spp. and double-species infections in patients with Alzheimer's disease

  NEMERGUT Michal BÁŤKOVÁ Tereza VIGAŠOVÁ Dana BARTOŠ Milan HLOZANKOVA Martina SMITH Andrea LIŠKOVÁ Barbora SHEARDOVÁ Kateřina VYHNALEK Martin HORT Jakub LACZO Jan KOVÁČOVÁ Ingrid ŠITINA Michal MATEJ Radoslav JANČÁLEK Radim MAREK Martin DAMBORSKÝ Jiří

  Article in Periodical

  Science of the Total Environment, year: 2022, volume: 844, edition: October 2022, DOI