Ing. RNDr. Martin Marek, Ph.D., MBA

2021

• Designované a syntetizované geny kódující nově zkonstruované proteinové katalyzátory (luciferázy) s ověřenými vlastnostmi

  MAREK Martin DAMBORSKÝ Jiří BEDNÁŘ David PLUSKAL Daniel MAJEROVÁ Marika PLANAS IGLESIAS Joan

  Outcomes put into operation (prototype, working sample)

  Year: 2021

• Engineering protein dynamics for the understanding of divergent evolution of the Renilla luciferase

  TOUL Martin SMITH Andrea RANGEL PAMPLONA PIZARRO PINTO José Gaspar MAREK Martin HERNYCHOVÁ Lenka LIŠKOVÁ Veronika PLUSKAL Daniel EMOND Stephane DÖRR Mark PLANAS IGLESIAS Joan CHALOUPKOVÁ Radka BEDNÁŘ David PROKOP Zbyněk BORNSCHEUER Uwe T. HOLLFELDER Florian DAMBORSKÝ Jiří

  Conference abstract

  Year: 2021, type: Conference abstract

• Engineering the protein dynamics of an ancestral luciferase

  SCHENKMAYEROVÁ Andrea RANGEL PAMPLONA PIZARRO PINTO José Gaspar TOUL Martin MAREK Martin HERNYCHOVÁ Lenka PLANAS IGLESIAS Joan LIŠKOVÁ Veronika PLUSKAL Daniel VAŠINA Michal EMOND Stephane DÖRR Mark CHALOUPKOVÁ Radka BEDNÁŘ David PROKOP Zbyněk HOLLFELDER Florian BORNSCHEUER Uwe T. DAMBORSKÝ Jiří

  Article in Periodical

  Nature Communications, year: 2021, volume: 12, edition: 1, DOI

• Species-selective targeting of pathogens revealed by the atypical structure and active site of Trypanosoma cruzi histone deacetylase DAC2

  MAREK Martin RAMOS-MORALES E. PICCHI-CONSTANTE G.F.A. BAYER T. NORSTROM C. HERP D. SALES P.A. GUERRA-SLOMPO E.P. HAUSMANN K. CHAKRABARTI A. SHAIK T.B. MERZ A. TROESCH E. SCHMIDTKUNZ K. GOLDENBERG S. PIERCE R.J. MOURAO MM JUNG M.M. SCHULTZ J. SIPPL W. ZANCHIN N.I.T. ROMIER C.

  Article in Periodical

  Cell Reports, year: 2021, volume: 37, edition: 12, DOI

• The structure of the mouse ADAT2/ADAT3 complex reveals the molecular basis for mammalian tRNA wobble adenosine-to-inosine deamination

  RAMOS-MORALES Elizabeth BAYAM Efil DEL-POZO-RODRIGUEZ Jordi SALINAS-GIEGE Thalia MAREK Martin TILLY Ramos-Morales, E (Ramos- WOLFF Philippe TROESCH Edouard ENNIFAR Eric DROUARD Laurence GODIN Juliette D. ROMIER Christophe

  Article in Periodical

  Nucleic acids research, year: 2021, volume: 49, edition: 11, DOI

2020

• Decoding the intricate network of molecular interactions of a hyperstable engineered biocatalyst

  MARKOVÁ Klára CHMELOVÁ Klaudia MARQUES Sérgio Manuel CARPENTIER Philippe BEDNÁŘ David DAMBORSKÝ Jiří MAREK Martin

  Article in Periodical

  Chemical Science, year: 2020, volume: 11, edition: 41, DOI

• Structural and catalytic effects of surface loop-helix transplantation within haloalkane dehalogenase family

  MAREK Martin CHALOUPKOVÁ Radka PRUDNIKOVA Tanyana SATO Yukari REZACOVA Pavlina NAGATA Yuji SMATANOVA KUTA Ivana DAMBORSKÝ Jiří

  Article in Periodical

  Computational and Structural Biotechnology Journal, year: 2020, volume: 18, edition: December 2020, DOI

• Structures of hyperstable ancestral haloalkane dehalogenases show restricted conformational dynamics

  BABKOVÁ Petra DUNAJOVÁ Zuzana CHALOUPKOVÁ Radka DAMBORSKÝ Jiří BEDNÁŘ David MAREK Martin

  Article in Periodical

  Computational and Structural Biotechnology Journal, year: 2020, volume: 18, edition: 2020, DOI

2019

• Functional switching based on altered enzyme flexibility via InDel mutagenesis of a reconstructed ancestor

  SCHENKMAYEROVA A. PINTO G. MAREK Martin TOUL Martin HERNYCHOVÁ Lenka LIŠKOVÁ Veronika EMOND S. BEDNÁŘ David PROKOP Zbyněk CHALOUPKOVÁ Radka HOLLFELDER F. BORNSCHEUER U.T.

  Conference abstract

  Year: 2019, type: Conference abstract

• Light-Emitting Dehalogenases: Reconstruction of Multifunctional Biocatalysts

  CHALOUPKOVÁ Radka LIŠKOVÁ Veronika TOUL Martin MARKOVÁ Klára ŠEBESTOVÁ Eva HERNYCHOVÁ Lenka MAREK Martin RANGEL PAMPLONA PIZARRO PINTO José Gaspar PLUSKAL Daniel WATERMAN Jitka PROKOP Zbyněk DAMBORSKÝ Jiří

  Article in Periodical

  ACS Catalysis, year: 2019, volume: 9, edition: 6, DOI