Mgr. Vladimír Rotrekl, Ph.D.

2025

• Arrhythmogenic Potential of Aminophylline and Its Modulation by Salbutamol: Insights from Human Pluripotent Stem Cell-Derived Cardiomyocytes

  PEŠL Martin KLIMOVIC Vrana BECKEROVÁ Deborah KABANOV Daniil SCUREK Martin BÉBAROVÁ Markéta BRAT Kristián PŘIBYL Jan STÁREK Zdeněk ROTREKL Vladimír

  Conference abstract

  Year: 2025, type: Conference abstract

• ARYTMOGENNÍ POTENCIÁL AMINOFYLINU A JEHO MODULACE SALBUTAMOLEM: POZNATKY Z KARDIOMYOCYTŮ ODVOZENÝCH Z LIDSKÝCH PLURIPOTENTNÍCH KMENOVÝCH BUNĚK

  PEŠL Martin VRANA Šimon BECKEROVÁ Deborah KABANOV Daniil ŠČUREK Martin BÉBAROVÁ Markéta BRAT Kristián PŘIBYL Jan ROTREKL Vladimír STÁREK Zdeněk

  Conference abstract

  Year: 2025, type: Conference abstract

• Carfilzomib-specific proteasome β5/β2 inhibition drives cardiotoxicity via remodeling of protein homeostasis and the renin-angiotensin-system

  MENDEZ-LOPEZ Max BEŠŠE Andrej ZUPPINGER Christian PEREZ-SHIBAYAMA Christian GIL-CRUZ Cristina FLOREA Bogdan I ANGELINA De Martin LUTGE Mechthild BECKEROVÁ Deborah VRANA Šimon ZHOU Xiang RASCHE Leo PŘIBYL Jan ROTREKL Vladimír LUDEWIG Burkhard OVERKLEEFT Herman S BEŠŠE Lenka DRIESSEN Christoph

  Article in Periodical

  iScience, year: 2025, volume: 28, edition: 9, DOI

• Dual-Organoid Biosensor for Monitoring2 Cardiac Conduction Disturbances In Vitro

  SVĚRÁK Filip KABANOV Daniil VRANA Šimon BECKEROVÁ Deborah MÁCHAL Jan PEŠL Martin ROTREKL Vladimír PŘIBYL Jan

  Article in Periodical

  Analytica Chimica Acta, year: 2025, volume: 2025, edition: 1, DOI

• Duchenne Muscular Dystrophy cardiac organoid development: increased DNA damage, hastened maturation and elevated inflammation

  BECKEROVÁ Deborah PEŠL Martin DOBROVOLNÁ Hana KYSELÁK Ondřej ROTREKL Vladimír

  Conference abstract

  Year: 2025, type: Conference abstract

• FGF2 supports NANOG expression via pyruvate dehydrogenase-dependent histone acetylation under low oxygen conditions

  FOJTÍK Petr ŠENFLUK Martin HOLOMKOVÁ Kateřina SALYKIN Anton GREGOROVÁ Jana ŠMAK Pavel PEŠ Ondřej RAŠKA Jan BECKEROVÁ Deborah ŠTĚTKOVÁ Monika SKLÁDAL Petr SEDLÁČKOVÁ Miroslava HAMPL Aleš BOHAČIAKOVÁ Dáša ULDRIJAN Stjepan ROTREKL Vladimír

  Article in Periodical

  Frontiers in Cell and Developmental Biology, year: 2025, volume: 13, edition: October 2025, DOI

2024

• Computer-aided engineering of stabilized fibroblast growth factor 21

  DE LA BOURDONNAYE Gabin GHAZALOVÁ Tereza FOJTÍK Petr KUTALKOVA Katerina BEDNÁŘ David DAMBORSKÝ Jiří ROTREKL Vladimír STEPANKOVA Veronika CHALOUPKOVÁ Radka

  Article in Periodical

  Computational and Structural Biotechnology Journal, year: 2024, volume: 23, edition: December 2024, DOI

• Hyaluronic acid-based hydrogels with tunable mechanics improved structural and contractile properties of cells

  KLIMOVIČ Šimon BECKEROVÁ Deborah VĚŽNÍK Jakub KABANOV Daniil LACINA Karel JELÍNKOVÁ Šárka GUMULEC Jaromír ROTREKL Vladimír PŘIBYL Jan

  Article in Periodical

  Biomaterials Advances, year: 2024, volume: 159, edition: May 2024, DOI

• Microphysiological Analysis of Cardiomyocyte Function in 3D Organoids

  PEŠL Martin SVĚRÁK Filip KABANOV Daniil KLIMOVIČ Šimon BECKEROVÁ Deborah ROTREKL Vladimír PŘIBYL Jan

  Conference abstract

  Year: 2024, type: Conference abstract

• Salbutamol attenuates arrhythmogenic effect of aminophylline in a hPSC-derived cardiac model

  KABANOV Daniil VRANA Šimon BECKEROVÁ Deborah MOLČAN Martin ŠČUREK Martin BRAT Kristián BÉBAROVÁ Markéta ROTREKL Vladimír PŘIBYL Jan PEŠL Martin

  Article in Periodical

  Scientific Reports, year: 2024, volume: 14, edition: 1, DOI