Project information
Czech Infrastructure for Integrative Structural Biology
(CIISB)
- Project Identification
- LM2015043
- Project Period
- 1/2016 - 12/2019
- Investor / Pogramme / Project type
-
Ministry of Education, Youth and Sports of the CR
- Large Infrastructures for Research, Development and Innovation
- MU Faculty or unit
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Central European Institute of Technology
- prof. RNDr. Vladimír Sklenář, DrSc.
The Czech Infrastructure for Integrative Structural Biology (CIISB) is a distributed infrastructure of the core facilities and central laboratories of CEITEC (Central European Institute of Technology, Brno) and BIOCEV (Biotechnology and Biomedicine Centre, Vestec, Prague-West) providing expertise and access to technologies used for integrative approaches to structural analysis of biologically important cellular components and macromolecules - proteins, nucleic acids, and their complexes. CIISB, equipped with the cutting-edge technologies (total investments will exceed 750 mil. CZK by the end of 2015), will offer access to the equipment and expertise in the following fields: high-field NMR spectroscopy; high throughput crystallization of biological macromolecules; X-ray diffraction techniques; Bio-SAXS measurements; AFM imaging; characterization of proteins, nucleic acids and complexes by biophysical methods including microcalorimetry, dynamic light scattering, and surface plasmon resonance; high-end cryo-electron microscopy and tomography allowing studies of cellular structures, organelles, and biomacromolecular complexes by 3D imaging; protein expression in eukaryotic cells; high-end mass spectrometry characterization of biomacromolecules; determination of protein post-translational modifications; MS-based peptide mapping/sequencing; high throughput sequencing and proteomic services. CIISB infrastructure aims to provide a high quality open access services in provision of methods and techniques on a level of national and trans-national importance. CIISB as National Affiliated Center is a part of the ESFRI projects INSTRUCT.
Publications
Total number of publications: 313
2019
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Atomic Force Microscopy (AFM) for Bio Applications
Year: 2019, type: Workshop
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Bambusuril analogs based on alternating glycoluril and xylylene units
Beilstein journal of organic chemistry, year: 2019, volume: 15, edition: June, DOI
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Bifurcated hydrogen bonds in platinum(II) complexes with phosphinoamine ligands
Polyhedron, year: 2019, volume: 170, edition: 15 September 2019, DOI
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Business Research Forum 2019 - CTT MUNI
Year: 2019, type: Popularization text
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Cell-Laden Hydrogel as a Clinical-Relevant 3D Model for Analyzing Neuroblastoma Growth, Immunophenotype, and Susceptibility to Therapies
Frontiers in Immunology, year: 2019, volume: 10, edition: AUG, DOI
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Cisplatin enhances cell stiffness and decreases invasiveness rate in prostate cancer cells by actin accumulation
Scientific reports, year: 2019, volume: 9, edition: 1660, DOI
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Click-conjugated photon-upconversion nanoparticles in an immunoassay for honeybee pathogen Melissococcus plutonius
Nanoscale, year: 2019, volume: 11, edition: 17, DOI
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Colicin Z, a structurally and functionally novel colicin type that selectively kills enteroinvasive Escherichia coli and Shigella strains
Scientific reports, year: 2019, volume: 9, edition: JUL 31 2019, DOI
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Common Metabolic Pathways Implicated in Resistance to Chemotherapy Point to a Key Mitochondrial Role in Breast Cancer
Molecular and Cellurar Proteomic, year: 2019, volume: 18, edition: 2, DOI
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Comparative Electrochemical and Spectroscopic Studies of I-motif forming DNA Nonamers
Electroanalysis, year: 2019, volume: 31, edition: 10, DOI