Project information

Visible light-activated photocaged molecules for biological applications (VLAMBA)

Project Identification
6SA17811
Project Period
5/2017 - 4/2020
Investor / Pogramme / Project type
South-Moravian Region
MU Faculty or unit
Faculty of Science

Using light as the control stimulus in biological settings offers unparalleled advantages in terms of availability, very high spatial and temporal precision, high orthogonality towards biochemical systems and lack of waste products. For therapeutic applications, wavelength of light plays a crucial role as only wavelengths between 600–1200 nm possess the ability to significantly penetrate living tissue. Unfortunately, with just a few examples available, direct photochemical release of molecules with wavelengths in the visible and near-infrared spectrum constitutes a significant challenge in contemporary chemistry. Therefore, the project aims to identify and develop new systems for visible light-induced release and control of biologically relevant functionalities (i.e. alcohols, carboxylic acids) or small molecules (i.e. gasotransmitters) to provide a platform for in vitro and potential in vivo applications. To this end, we seek to utilize well-established and biocompatible chromophores and use computational chemistry for rational design of the candidates. Upon successful demonstration of photochemical release under biologically compatible conditions, the system will be applied in biological and in vitro studies.

Publications

Total number of publications: 2