Project information
Minimal nephroprospective measures in prophylaxis of conventional amphotericin B-induced nephrotoxicity in oncological patients
- Project Identification
- NL6514
- Project Period
- 1/2001 - 1/2003
- Investor / Pogramme / Project type
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Ministry of Health of the CR
- R&D of Pharmacology and Pharmacy
- MU Faculty or unit
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Faculty of Medicine
- prof. MUDr. Drahomír Horký, DrSc.
- Cooperating Organization
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University of Veterinary Sciences Brno
- Responsible person Doc. MVDr. Jaroslav Doubek , CSc.
- Responsible person prof. MUDr. Michael Doubek, Ph.D.
Prophylaxis of conventional amphterin B-induced renal toxicity in oncological patients by vigorous hydration of patients, and ion supplementation corresponding the amounts lost by the kidneys during amphotericin B therapy. Part of the project is experiment in laboratory rats, where we plan to evaluate at full lenght the amphotericin B-induced renal toxicity and efficary of prophylactic nephroprotective measures.
Publications
Total number of publications: 13
2004
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Changes of nephron of laboratory rat after administration of Amphotericin B colloidal dispersion and conventional Amphotericin B deoxycholate -morphology and morphometry study
Sborník abstrakt 42.kongresu Slovenské anatomické společnosti s mezinárodní účastí, year: 2004
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Influence of Amphotericin B Deoxycholate or Amphotericin B Colloidal Dispersion on Renal Tubule Epithelium in Rat
Biomedical Papers, year: 2004, volume: 148, edition: 2
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Influence of amphotericin B deoxycholate or amphotericin B colloidal dispersion on renal tubules epithelium in rat.
V. Moravský Morfologický Den - Program a Sborník abstrakt, year: 2004
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Morfologické změny ledvinné tkáně laboratorního potkana po podání amfotericinu B deoxycholátu a amfotericinu B koloidní disperze.
Sborník prác venovaných 80. narodeninám prof. MUDr. G. Čierneho, DrSc., year: 2004
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Ultrastructural Morphometry of Renal Tubule Epithelium in Rat Treated with Conventional Amphotericin B deoxycholate B or Amphotericin B Colloidal Dispersion.
Acta Veterinaria Brno, year: 2004, volume: 2004, edition: 73
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Ultrastructural Morphometry of renal Tubule Epithelium in Rats Treated with Conventional Amphotericin B Deoxycholate or Amphotericin B Colloidal Dispersion
Acta Vet., year: 2004, edition: 73
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Ultrastructural morphometry of renal tubule epithelium in rats treated with conventional amphotericin B deoxycholate or amphotericin B colloidal dispersion
Acta veterinaria (Brno), year: 2004, volume: 73, edition: 3
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Vliv konvenčního amfotericinu B deoxicholátu a jeho koloidní disperze na ultrastrukturu epitelu renálních tubulů v ledvině laboratorního potkana - morfometrická analýza
Zborník prác, year: 2004
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Vliv konvenčního amfotericinu B deoxycholátu a jeho koloidní disperze na ultrastrukturu epitelu renálních tubulů v ledvině laboratorního potkana - morfometrická analýza
Sborník prác venovaných 80. narodeninám prof. MUDr. G. Čierneho, DrSc., year: 2004
2003
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Changes of rat kidneys after administration of Amphotericin B colloidal dispersion and conventional Amphotericin B deoxycholate. Morphological observation.
Scripta medica (Brno), year: 2003, volume: 76/2003, edition: 4