Project information
Czech Infrastructure for Integrative Structural Biology
(CIISB)
- Project Identification
- LM2018127
- Project Period
- 1/2020 - 12/2022
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Large Infrastructures for Research, Development and Innovation
- MU Faculty or unit
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Central European Institute of Technology
- prof. RNDr. Vladimír Sklenář, DrSc.
- Cooperating Organization
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Institute of Biotechnology CAS
The Czech Infrastructure for Integrative Structural Biology (CIISB) is a distributed infrastructure of the core facilities and central laboratories of CEITEC (Central European Institute of Technology, Brno) and BIOCEV (Biotechnology and Biomedicine Centre, Vestec) providing expertise and access to technologies used for integrative approaches to structural analysis of biologically important cellular components and macromolecules - proteins, nucleic acids, and their complexes. CIISB, equipped with the cutting-edge technologies, will offer access to the equipment and expertise in the following fields: high-field NMR spectroscopy; high throughput crystallization of biological macromolecules; X-ray diffraction techniques; Bio-SAXS measurements; AFM imaging; characterization of proteins, nucleic acids and complexes by biophysical methods including microcalorimetry, dynamic light scattering, and surface plasmon resonance; high-end cryo-electron microscopy and tomography allowing studies of cellular structures, organelles, and biomacromolecular complexes by 3D imaging; protein expression in eukaryotic cells; high-end mass spectrometry characterization of biomacromolecules; determination of protein post-translational modifications; MS-based peptide mapping/sequencing; high throughput sequencing and proteomic services. CIISB infrastructure aims to provide a high quality open access services in provision of methods and techniques on a level of national and trans-national importance. CIISB is a part of the ESFRI project INSTRUCT-ERIC.
Sustainable Development Goals
Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.
Publications
Total number of publications: 327
2022
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Detailed analysis of binding sites in the PLL family
Year: 2022, type: Conference abstract
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Diethyl ether anesthesia induces transient cytosolic [Ca2+] increase, heat shock proteins, and heat stress tolerance of photosystem II in Arabidopsis
Frontiers in Plant Science, year: 2022, volume: 13, edition: SEP, DOI
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Differentiation of Sialyl Linkages Using a Combination of Alkyl Esterification and Phenylhydrazine Derivatization: Application for N-Glycan Profiling in the Sera of Patients with Lung Cancer
ANALYTICAL CHEMISTRY, year: 2022, volume: 94, edition: 18, DOI
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Dual cardiomyocyte cluster detection the different types of arrhythmogenic potential of caffein
Year: 2022, type: Conference abstract
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Ecological specialization and reproductive isolation among closely related sympatric ant-eating spiders
Journal of Animal Ecology, year: 2022, volume: 91, edition: 9, DOI
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Effects of salbutamol and ipratropium on human stem-cells derived cardiomyocytes’ function
Year: 2022, type: Conference abstract
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Enhanced drug delivery by a prodrug approach effectively relieves neuroinflammation in mice
Life Sciences, year: 2022, volume: 310, edition: DEC, DOI
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Exkurze studentů Biskupského gymnázia
Year: 2022, type: Popularization text
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Exkurze studentů Gymnázia Brno-Řečkovice
Year: 2022, type: Popularization text
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Extended Mechanism of the Plasminogen Activator Staphylokinase Revealed by Global Kinetic Analysis: 1000-fold Higher Catalytic Activity than That of Clinically Used Alteplase
ACS Catalysis, year: 2022, volume: 12, edition: 7, DOI