Czech Infrastructure for Integrative Structural Biology (CIISB)
- Kód projektu
- LM2018127
- Období řešení
- 1/2020 - 12/2022
- Investor / Programový rámec / typ projektu
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Ministerstvo školství, mládeže a tělovýchovy ČR
- Velké infrastruktury pro výzkum, vývoj a inovace
- Fakulta / Pracoviště MU
- Středoevropský technologický institut
- Spolupracující organizace
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Biotechnologický ústav AV ČR, v.v.i.
The Czech Infrastructure for Integrative Structural Biology (CIISB) is a distributed infrastructure of the core facilities and central laboratories of CEITEC (Central European Institute of Technology, Brno) and BIOCEV (Biotechnology and Biomedicine Centre, Vestec) providing expertise and access to technologies used for integrative approaches to structural analysis of biologically important cellular components and macromolecules - proteins, nucleic acids, and their complexes. CIISB, equipped with the cutting-edge technologies, will offer access to the equipment and expertise in the following fields: high-field NMR spectroscopy; high throughput crystallization of biological macromolecules; X-ray diffraction techniques; Bio-SAXS measurements; AFM imaging; characterization of proteins, nucleic acids and complexes by biophysical methods including microcalorimetry, dynamic light scattering, and surface plasmon resonance; high-end cryo-electron microscopy and tomography allowing studies of cellular structures, organelles, and biomacromolecular complexes by 3D imaging; protein expression in eukaryotic cells; high-end mass spectrometry characterization of biomacromolecules; determination of protein post-translational modifications; MS-based peptide mapping/sequencing; high throughput sequencing and proteomic services. CIISB infrastructure aims to provide a high quality open access services in provision of methods and techniques on a level of national and trans-national importance. CIISB is a part of the ESFRI project INSTRUCT-ERIC.
Publikace
Počet publikací: 54
2021
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Detection of organic dyes by surface-enhanced Raman spectroscopy using plasmonic NiAg nanocavity films
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, rok: 2021, ročník: 249, vydání: March 2021, DOI
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Hexagonal Microparticles from Hierarchical Self-Organization of Chiral Trigonal Pd3L6 Macrotetracycles
Cell Reports Physical Science, rok: 2021, ročník: 2, vydání: 1, DOI
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Modes of Micromolar Host-Guest Binding of beta-Cyclodextrin Complexes Revealed by NMR Spectroscopy in Salt Water
The Journal of Organic Chemistry, rok: 2021, ročník: 86, vydání: 6, DOI
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Myeloperoxidase mediated alteration of endothelial function is dependent on its cationic charge
Free Radical Biology and Medicine, rok: 2021, ročník: 162, vydání: January 2021, DOI
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New mixed-ligand organoaluminum heteroarylalkenolates
Polyhedron, rok: 2021, ročník: 2021, vydání: 194, DOI
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N-Glycome changes reflecting resistance to platinum-based chemotherapy in ovarian cancer
JOURNAL OF PROTEOMICS, rok: 2021, ročník: 230, vydání: JAN, DOI
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Synthesis of high surface area aluminophosphate and -phosphonate xerogels by non-hydrolytic sol-gel reactions
Microporous and Mesoporous Materials, rok: 2021, ročník: 311, vydání: February 2021, DOI
2020
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A Model of Aerobic and Anaerobic Metabolism of Hydrogen in the Extremophile Acidithiobacillus ferrooxidans
Frontiers in Microbiology, rok: 2020, ročník: 11, vydání: November 2020, DOI
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A Photochemical/Thermal Switch Based on 4,4'-Bis(benzimidazolio)stilbene: Synthesis and Supramolecular Properties.
ChemPhysChem, rok: 2020, ročník: 21, vydání: 18, DOI
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Activation of glycogenolysis and glycolysis in breast cancer stem cell models
Biochimica et Biophysica Acta - Molecular Basis of Disease, rok: 2020, ročník: 1866, vydání: 10, DOI