Project information

Elucidating the role of the RNA editing enzyme ADAR1 in novel biological pathways and determine its posttranslational regulation.

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Project Identification
GA20-11101S
Project Period
1/2020 - 12/2022
Investor / Pogramme / Project type
Czech Science Foundation
MU Faculty or unit
Central European Institute of Technology

ADARs converts adenosine to inosine in double-stranded RNA and this is one of the most abundant modifications found in RNA. Previously, my group has demonstrated the pivotal role of ADAR1 in innate immunity. However there is also an editing independent function of ADAR1 that is important but currently unknown. We propose to uncover this editing independent function by investigating proteins that interact with ADAR1. We have preliminary data on the interaction of ADAR1 with differential protein complexes when cells are treated with α-interferon. We will analyse this data, validate protein interactions and map which biological pathways ADAR1 has a direct influence on and whether it depends on the enzymatic activity.
It has been predicted that ADAR1 is highly modified posttranslationally and this may account for variation in its activity in different cell types. The second aim is to elucidate if these posttranslational modifications regulate ADAR1, in particular those modifications of ADAR1 that occur after type 1 interferon induction.

Sustainable Development Goals

Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.

Sustainable Development Goal No.  3 – Good health and well-being Sustainable Development Goal No.  4 – Quality education Sustainable Development Goal No.  5 – Gender equality Sustainable Development Goal No.  9 – Industry, innovation and infrastructure Sustainable Development Goal No.  15 – Life on land

Publications

Total number of publications: 5


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