Project information

Novel individualized brain stimulation network-based approaches to improve cognition in healthy seniors and patients with MCI

Project Identification
Project Period
1/2021 - 6/2024
Investor / Pogramme / Project type
Czech Science Foundation
MU Faculty or unit
Central European Institute of Technology
Cooperating Organization
École Polytechnique Fédérale de Lausanne

Impaired working memory (WM) plays a crucial role in normal aging, in mild cognitive impairment (MCI) and cognitive decline associated with dementia, such as Alzheimer's disease (AD). The aging-related differences in WM are hypothesized to be derived from various neurobiological roots, from which the alterations in the dynamic interplay between the large-scale brain networks have proven an important role. Recent studies have shown that cerebellar stimulation could further modulate the parts of large-scale brain networks. Non-invasive brain stimulation (NIBS) methods are capable of modulation of brain plasticity and activity. We hypothesize that we will be able to identify a multifocal NIBS
protocol that can improve working memory. By successive and concurrent stimulation of multiple brain regions by transcranial alternating current stimulation (tACS) and/or
repetitive transcranial magnetic stimulation (rTMS) we will study dynamic interaction between distinct cortico-cortical and subcortico-cortical brain areas. By leveraging the mechanistic aspects derived from multifocal stimulation, we aim to develop a novel closed-loop procedure utilizing EEG and tACS that would inject current based on the 'online' status of the fronto-parietal domain general nodes in healthy seniors and MCI-AD patients.

Sustainable Development Goals

Masaryk University is committed to the UN Sustainable Development Goals, which aim to improve the conditions and quality of life on our planet by 2030.

Sustainable Development Goal No.  5 – Gender equality Sustainable Development Goal No.  8 – Decent work and economic growth Sustainable Development Goal No.  10 – Reduced inequalities


Total number of publications: 1

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