Project information
Cytoskeleton in human pathogenic yeast microorganisms
- Project Identification
- GA310/00/0391
- Project Period
- 1/2000 - 1/2002
- Investor / Pogramme / Project type
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Czech Science Foundation
- Standard Projects
- MU Faculty or unit
- Faculty of Medicine
The proposed project is based on the contemporary knowledge of functions of actin and microtubular cytoskeleton in cell reproduction of the yeasts S. cerevisiae, S. japonicus var. versatilis and S. pombe. In area of basic research the project has the aim :(i) to detect actin and microtubular cytoskeleton in human pytogens Cryptococcus neoformans, Malassezia pachydermatis and Aureobasidium pullulans; (ii) to find out the effects of antiactin and antimicrotubular inhibitors on their cytoskeleton in vitro; (iii) to detect, if any inhibitors would destroy actin cables, rings and especially actin "patches"- actin structure specific for fungi; (iv) to identify, if any of antimicritubular inhibitors would destroy microtubules, and especially SPB-structures, sp ecific for fungi; (v) to suggest the most effective combination of antiactin and antimicrotubular inhibitors to block proliferation of human pathogens in vitro. The results pbtained may represent a theoretical basis for further possible causal therapy of
Publications
Total number of publications: 25
2003
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The first findings on the microtubule cytoskeleton in Malassezia pachydermatis
Year: 2003, type: Conference abstract
2002
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The study of potentially pathogenic lipophilic yeast Malassezia pachydermatis
Year: 2002, type: Conference abstract
2001
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Cytoskeleton in human pathogenic yeasts Cryptococcus neoformans and Aureobasidium pullulans and the effect of cytoskeletal inhibitors.
YEAST, year: 2001, volume: 18, edition: Number S1
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CYTOSKELETON IN THE CELL CYCLE OF CRYPTOCOCCUS NEOFORMANS AND THE EFFECTS OF CYTOSKELETAL INHIBITORS
XXIX.Výrocná konferencia o kvasinkách, Kongresové centrum SAV Smolenice, year: 2001
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Characterization of a fission yeast mutant which displays defects in cell wall integrity and cytokinesis
Genes Genet. Syst., year: 2001, volume: 76, edition: 4
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Microtubules and actin cytoskeleton in Cryptococcus neoformans compared with ascomycetous budding and fission yeasts
Europen Journal of Cell Biology, year: 2001, volume: 80, edition: April issu
2000
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Cytoskelet a ultrastruktura u některých lidských houbových patogenů.
Sborník z XXVIII. výroční konference o kvasinkách Smolenice 15.-17.5.2000, year: 2000
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Cytoskeleton and morphological aberrations of septum formation and cytokinesis in cps6 mutant of Schizosaccharomyces pombe
VII. Cytoskeletální klub, year: 2000
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Cytoskeleton and ultrastructure in some human fungal pathogens
Folia Microbiologica, year: 2000, volume: 45, edition: 1
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Cytoskeleton in some pathogenic fungi
VIII. Cytoskeletální klub Čs. Biol. Spol. Vranovská Ves 15.-17.3.2000, year: 2000