Project information
Cytoskeleton in human pathogenic yeast microorganisms
- Project Identification
- GA310/00/0391
- Project Period
- 1/2000 - 1/2002
- Investor / Pogramme / Project type
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Czech Science Foundation
- Standard Projects
- MU Faculty or unit
- Faculty of Medicine
The proposed project is based on the contemporary knowledge of functions of actin and microtubular cytoskeleton in cell reproduction of the yeasts S. cerevisiae, S. japonicus var. versatilis and S. pombe. In area of basic research the project has the aim :(i) to detect actin and microtubular cytoskeleton in human pytogens Cryptococcus neoformans, Malassezia pachydermatis and Aureobasidium pullulans; (ii) to find out the effects of antiactin and antimicrotubular inhibitors on their cytoskeleton in vitro; (iii) to detect, if any inhibitors would destroy actin cables, rings and especially actin "patches"- actin structure specific for fungi; (iv) to identify, if any of antimicritubular inhibitors would destroy microtubules, and especially SPB-structures, sp ecific for fungi; (v) to suggest the most effective combination of antiactin and antimicrotubular inhibitors to block proliferation of human pathogens in vitro. The results pbtained may represent a theoretical basis for further possible causal therapy of
Publications
Total number of publications: 25
2015
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Microtubules and Actin Cytoskeleton of Cryptococcus neoformans as Targets for Anticancer Agents to Potentiate a Novel Approach for New Antifungals
Chemotherapy, year: 2015, volume: 61, edition: 3, DOI
2014
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Effects of Microtubule and Actin Inhibitors on Cryptococcus neoformans Examined by Scanning and Transmission Electron Microscopy
Chemotherapy, year: 2014, volume: 60, edition: 2, DOI
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The Effects of the F-Actin Inhibitor Latrunculin A on the Pathogenic Yeast Cryptococcus neoformans
Chemotherapy, year: 2014, volume: 60, edition: 3, DOI
2009
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Microtubules and actin cytoskeleton of potentially pathogenic basidimycetous yeast as target for antifungals
CHEMOTHERAPY, year: 2009, volume: 55, edition: 4
2007
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Studium cytoskeletu a ultrastrukturální charakteristika vybraných patogenních kvasinek - Malassezia pachydermatis a Cryptococcus laurentii
Year: 2007, number of pages: 124 s.
2006
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The cytoskeleton in the unique cell reproduction by conidiogenesis of the long-neck yeast Fellomyces (Sterigmatomyces) fuzhouensis.
Protoplasma, An International Journal of Cell Biology. 6., year: 2006, volume: 229, edition: 1:
2004
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CONIDIOGENESIS IN PATHOGENIC FUNGI: CYTOSKELETON AS TARGET FOR ANTIFUNGALS- INVITED LECTURE
8th Asia-Pacific Conference on Electron Microscopy (8APEM), year: 2004
2003
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Analysis of microtubules and F-actin structures in hyphae and conidia development of the opportunistic human pathogenic black yeast Aureobasidium pullulans
Microbiology, year: 2003, volume: 149, edition: 4
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Development of antifungals against the black yeast
MICROBIOLOGY TODAY, year: 2003, volume: 30, edition: May 2003
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The Cytoskeleton during the Conidiogenesis.
XI. Cytoskeletální klub Vranovská Ves 23.-25.4.2003, year: 2003